Error Readout:
HTTP Error 404 - File Not Found
HTTP Error 404- File or Directory not found

Fix:
Enable a Pre-existing Web Service Extension in IIS 6.0

To permit IIS to serve content that requires a specific ISAPI or CGI extension that is already listed in the Web service extensions list, follow these steps:

1. Open IIS Manager, expand the master server node (that is, the Servername node), and then select the Web service extensions node.
2. In the right pane of IIS Manager, right-click the extension that you want to enable. In this example, this is Active Server Pages.
3. Click to select the Allow check box.

Microsoft Link: http://support.microsoft.com/kb/315122

Explanation:
Apparently there was no easy Google search for this stupidly easy fix. (UPDATE: I'm wrong Google the title of this blog entry and a Microsoft fix is the first result) Consequently, I spent more time than I would like on trying to fix it.

Here is how it went down. I recive a HTTP Error 404 - File Not Found error on a page I was browsing to from IIS 6.0. How could this be I ask myself, the page does exists, I know because I see it in IIS 6.0, I right click the file and I select browse. WTF. Upon a little investigation I found out what was wrong and I found a Microsoft website furthers my fix. Soooo  easy! Anyways moving on, going to go drink a beer and forget this time was lost in which I will never get back.